Skip to main content

Senior Scientist - Protein Binder Discovery

Employer
CK Group
Location
Cambridge
Salary
Competitive
Closing date
6 Jun 2024

View more

Sector
Biology
Contract Type
Permanent
Hours
Full Time

Job Details

CK Group are working in partnership with Nxera Pharma UK Limited (formerly Sosei Heptares) to recruit a lab-based Senior Scientist in Protein Binder Discovery based in Granta Park, Cambridge.

Company:
Nxera Pharma is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally, focused on therapeutic areas in inflammation diseases, neurology and immunology. 
 
The Role:
The successful candidate will join the Protein Binders Discovery Team at Nxera Pharma and will also be part of the wider Biochemistry and Biophysics teams. The successful candidate will use phage display expertise to select protein binders against therapeutic membrane protein targets to enable structure determination and drug discovery efforts. 

The role will include the following responsibilities:
  • Screening phage display libraries against membrane protein targets 
  • Protein engineering of VHH frameworks
  • Subcloning of plasmid constructs for expression 
  • Biophysical evaluation of VHH hits

Your Background:
  • PhD (or MSc with equivalent lab experience) in a relevant area of biology
  • Theoretical and practical expertise in phage display technologies and selection techniques 
  • Experience working with phage antibody libraries and preferably VHH display
  • Strong and evidenced molecular biology proficiency 
  • Experience of screening techniques (eg ELISA, cell binding assays etc)
  • Experience of affinity maturation
  • Analytical thinking and good problem-solving skills
DESIRABLE:
  • Experience of measuring affinity using either BLI or SPR
  • Experience of library build (either affinity maturation or immunised, naïve or synthetic libraries)
  • Experience in working with membrane proteins (in particular GPCRs)
  • Computational expertise focussed around protein binder design would be advantageous
 
Apply:
It is essential that applicants hold entitlement to work in the UK. Please quote job reference 99230 in all correspondence.

Company

Find the career you always dreamed of

We are the CK Group, the UK’s specialist in scientific, clinical and technical recruitment.

We have 4 brands:  

  • CK Science is the leading independent scientific recruitment consultancy.
  • CK Clinical is an established leader in the clinical research and drug development sectors
  • CK Technical specialises in jobs for Engineers and IT professionals
  • CK QLS finds roles for high calibre professionals working in the science and technology sectors in Switzerland.

Over the last 28 years we have found jobs for thousands of high calibre scientists in the scientific, chemical, waste, biotechnology and pharmaceutical industries. By working with us to find your next job, you will get access to the best scientific vacancies in the UK, Europe and the rest of the world.

We are proud to be working with 18 out of the world’s top 20 scientific organisations.

We can help you find your dream job.

ckscience.co.uk

Company info
Website
Telephone
+44 (0)1246 457700
Location
CK Group
Westwick House
The Bridge Business Centre
Beresford Way
Chesterfield
S41 9FG
GB

Apply for Senior Scientist - Protein Binder Discovery

Fields marked with an asterisk (*) are required

Your file must be a .doc, .pdf, .docx, or .rtf. No larger than 1MB
Selected file:
Your communication preferences

When you apply for a job we will send your application to the named employer, who may contact you. By applying for a job listed on Chemistry World Jobs you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please contact us. All emails will contain a link in the footer to enable you to unsubscribe at any time.

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert