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Principal Scientist - Computational Chemistry

Domainex Ltd
Saffron Walden, Essex
Closing date
15 Feb 2023

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Job Details

About Us: 

Domainex is a multi-award winning integrated drug discovery CRO that has been setting the highest standards in drug discovery, with a particular emphasis on small molecule research, since 2001. We work in partnership with clients from a variety of sectors including academic, pharmaceutical, biotechnology and patient foundation organisations around the world.   Our vision is to be the pre-eminent partner for innovative drug discovery services that improve the quality of life for people living with disease. 

We offer our clients tailored services for every step of the drug discovery process, from expression of recombinant proteins and screening against disease targets to identify hit compounds, through the design and medicinal chemistry optimisation of hits and leads, to take these all the way to pre-clinical drug candidates

Our multidisciplinary team of scientists works closely with our partners to generate innovative ideas, and to deliver high-quality results and outputs (e.g. crystallography-grade proteins and novel compounds that meet the desired target product profile.

We have established a strong reputation with a very high level of repeat business and a proven record of success, some of which we can illustrate through the publications and case studies our clients have allowed us to put in the public domain. We have received several awards recognising our customer focus and innovative approach to drug discovery.


What Are We Looking For In This Exciting New Role?

When you join Domainex we will be looking for you to have the ability to - 

  • Utilize a platform of computational chemistry techniques to deliver programs of research for client sponsored projects
  • Apply your knowledge of computational chemistry within a drug discovery setting to influence clients to pursue further value-creating research projects
  • In conjunction with the Domainex leadership team proactively contribute and drive implementation of new computational chemistry tools and services
  • Seek to publish articles/papers, posters and patents to contribute to upholding the strong scientific reputation of Domainex in the market place
  • Line manage up to 1 scientist and set their research goals
  • Support the business development team by providing technical input in securing new business

What Educational Background Are We Expecting?

  • A PhD in Computational Chemistry

What Experience Will You Have?

  • Hold > 5 years of experience as a computational chemist within a professional drug design environment or organization
  • A sound knowledge of general computational chemistry techniques including open source packages
  • Experience in the areas of SBDD and virtual screening highly preferred but not mandatory
  • Proven experience of working with small molecules and knowledge of compound design principles
  • A good understanding of the related drug discovery disciplines necessary to support drug discovery programs, such as chemistry and structural biology
  • Versed in the use of pipelining tools, such as Knime, within a drug discovery setting Experience with Linux and high-performance computing
  • Effective verbal and written communication skills
  • Motivated and pro-active for addressing new challenges and providing solutions
  • Evidence of a high level of soft skills and the fostering of cross discipline relationships
  • Working within multi-disciplinary project teams
  • Track record of training and mentoring more junior computational chemists preferred but not mandatory.

What Can We Offer You?

Your highly competitive salary will be determined by your qualifications and your experience along with our excellent benefits package of a 5% pension contribution from yourself with a 10% contribution by Domainex; a private medical insurance scheme for you with discounted benefits for your family; annual leave of 25 days plus bank holidays and a day off for your birthday; loyal service awards and other great benefits such as discounted gym membership and a lift share scheme.

We are based on the Chesterford Research Park just outside of the charming market town of Saffron Walden, fifteen miles from the expansive city of Cambridge.   Chesterford Research Park has fabulous facilities including a restaurant, a gym, a six hole golf course and woodland walks.  

We welcome all applications into our already diverse and inclusive workplace where we do all we can to assist each and every member of our fantastic team to reach their full potential in their chosen field.   Feel free to apply for this role today or drop us a line to have a chat as there may be other options for you to explore within our growing organisation.


Domainex is an award-winning drug discovery service company that works in partnership with clients from a variety of sectors (including pharmaceutical, biotechnology, academic and patient foundations) around the world. Our approach to drug discovery is truly integrated. We offer the full range of pre-clinical drug discovery services supporting our clients at every stage of the journey, from disease target nomination to candidate drug selection.

From protein production, assay development and hit identification through to medicinal chemistry for lead optimisation, our dedicated experts work collaboratively with our clients to provide tailored scientific solutions, adding significant value to their drug discovery projects. Our innovative, customised suites of biology and chemistry technologies are designed to maximise efficiency and our integrated approach has a proven record of success in delivering timely and cost-effective solutions and generating new intellectual property.

We have established a number of proprietary technology platforms that differentiate us from our competitors, for example: Combinatorial Domain Hunting (CDH) is our patented technology for generating many thousands of variants of target proteins to identify suitable novel constructs which can subsequently be used in assays or for structural biology; LeadBuilder is our novel virtual screening platform which identifies hit compounds for our client’s drug discovery programmes in a rapid and cost-effective manner; FragmentBuilder is our integrated platform for performing fragment-based drug discovery (FBDD); PoLiPa is our technology which allows membrane proteins to be purified without the need for thermostabilizing mutations or detergents.

There are numerous small molecule drug discovery service companies throughout the world but there are relatively few that can provide a truly integrated offering. We have built up a strong reputation for technical excellence and innovation and always look to customize our proposals based on our clients’ specific needs. Our clients value this tailored input and we believe this differentiates us from other providers. Our scientists have a wealth of experience of working in industry (across a wide range of disease settings and biological target classes), with on average >10 years of drug discovery experience gained at both Domainex and at other leading pharmaceutical and biotechnology companies. Our scientists are also highly skilled/educated with >75% having obtained a PhD prior to joining Domainex.

The Domainex team is a diverse group, reflecting the multi-cultural Cambridge environment. Currently our team is made up of >10 nationalities; indeed over 30% of our staff have their origins from outside of the UK. Our team speak over 10 different languages as their mother tongues. This has the advantage that we are often able to offer our overseas clients a native speaker to ensure their wishes are being fully understood. We have also translated parts of our website into multiple languages to better communicate our service offerings to potential clients.

Company info
01223 433192
Chesterford Research Park
Little Chesterford
Saffron Walden
CB10 1XL

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