Senior Scientist, Dissolution & Biopharm Specialist, Analytical R&D

Employer
Pfizer
Location
Sandwich, UK
Salary
Unspecified
Closing date
2 Jun 2022

Job Details

Why Patients Need You 

Here at Pfizer, we have a specific purpose – to find breakthroughs that change patients' lives.  We are a patient centric company, guided by our four values: courage, joy, equity and excellence.  Our breakthrough culture lends itself to our dedication to transforming millions of lives.   

Our Pharmaceutical Sciences Department, part of Pfizer Worldwide R&D and Medical in Sandwich, UK, plays a critical role in transforming patients’ lives around the world by providing the process technology and analytical support for the development and manufacture of medicines at all phases of clinical development.   

We are seeking scientists with excellent technical skills, who want to learn more and have a desire to shape analytical development strategies for new drug candidates, to join our dynamic and highly talented Analytical Research and Development group in Sandwich. 

 

Job Focus  

The successful candidate will have a strong track record in chemistry, formulation science, pharmaceutical sciences, or analytical chemistry, and will support the development of Pfizer’s Pharmaceutical Sciences Small Molecule portfolio through the development and application of dissolution and advanced in-vitro methods for the prediction of clinical performance and ultimately to steer formulation development. 

They will work with cross-functional development teams collaborating with analytical chemists, and formulation scientists from across Pfizer’s global organisation, applying their knowledge of dissolution science, advanced in-vitro tools, and the relevant regulatory requirements to the development of Pfizer’s solid oral drug product portfolio. The colleague will have the ability to learn new techniques and develop new approaches in the pursuit of in-vitro prediction of clinical performance and work with other subject matter experts to solve complex problems. 

 

Responsibilities  

  • Working closely with drug product development teams develop and validate dissolution methods which are compliant with contemporary regulatory requirements for Pfizer’s portfolio of solid oral products.  Employ dissolution and advanced in-vitro tools to inform the development of novel, innovative, breakthrough medicines in clinical development, including treatments for Covid-19, rare infectious disease, cancer and other life-threatening conditions.  Effectively collaborate with project team members, including presenting data at project team meetings, critically reviewing experimental data and be actively involved in solving technical challenges that arise during pharmaceutical development.  Team interaction is critical, and the colleague must be able to collaborate with and mentor peers as well as effectively interact with leaders as part of a multi-disciplinary team, thriving in a fast-paced environment.  May represent the analytical department on global, cross-functional project teams and initiatives.   May author internal and external publications and relevant sections of CMC regulatory documentation, e.g. IND, IMPD, CTDs.  Provide technical coaching/mentoring to colleagues within project teams and the wider department.   Provide presentations, training and advice to others to share learnings and promote increased scientific and technical understanding of dissolution and biorelevant methods.  Be a positive advocate for new technology, process improvements and for the application of computational tools and digital design approaches.   Maintain written records of experimental work in accordance with GLP/GMP and departmental philosophies. 

 

Qualifications

Honours or Master's degree in Analytical Chemistry, Pharmaceutical Sciences, Chemistry or a related discipline with a high degree classification (e.g. equivalent of U.K. 1st or 2nd class). 

PhD degree in Analytical Chemistry, Pharmaceutical Sciences, or a related field, or 5+ years of experience in the pharmaceutical industry in a relevant role. 

 

Skills and Experience

  • Sound knowledge of dissolution development and related regulatory considerations.  A team orientated person with experience in a laboratory environment in the pharmaceutical industry is highly desirable.  Excellent communication skills are essential for this highly interactive position.  Excellent team collaboration and organisational skills are also essential.  A rational approach to problem solving with strong attention to detail and a desire to learn and grow their skills is essential.  A good appreciation of small molecule pharmaceutical development and an ability to apply scientific technical skills and knowledge to projects independently and proactively.   Experience in contributing to the authoring external technical publications and/or CMC regulatory submissions is desirable.  High level of practical competence with good laboratory safety awareness is expected.  Knowledge and experience of the use of computational, modelling and simulation tools would be beneficial, as would databasing and programming skills. 

 

#LI-PFE

Company

Here at Pfizer, we have a specific purpose – to find breakthroughs that change patients' lives. At Pfizer we are a patient centric company, guided by our four values: courage, joy, equity, and excellence.  Our breakthrough culture lends itself to our dedication to transforming millions of lives. 

 

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