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Senior Oligo Synthesis Scientist

Aptamer Group plc
York, North Yorkshire (GB)
Salary range £27,500- £31,500, dependent on skills and experience
Closing date
20 Feb 2022

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Contract Type
Full Time
Accreditation Requirements
Not specified
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We are growing and growing fast. Aptamer Group is a leading developer of next-generation molecular tools to enable innovation across the life sciences. We employ a diverse and talented team of high calibre scientists and commercial professionals located at our state-of-the-art development facility in York, UK.

Job Description

The oligo synthesis scientist will play a key role in our aptamer production workflow, they will be working closely with both the production and R&D team to fulfil customer and research related goals. The successful candidate will be responsible for the design, synthesis, and analysis of oligonucleotides.

Our ideal candidate will:

  • fit with our company culture.
  • have a positive, ‘can do’ attitude
  • possess good technical skills
  • work alongside members of the production team in an engaging and enthusiastic manner and support the culture of timely and efficient project delivery
  • be able to work as part of a highly motivated team to deliver parallel customer projects against defined specifications, to a highly controlled timeline and well-defined processes
  • have excellent synthetic chemistry skills


  • Design and perform automated high throughput solid-phase synthesis, purification, and analysis of novel oligonucleotides with chemical modifications.
  • Operate and maintain oligonucleotide synthesis platforms
  • Perform analysis of oligonucleotides by HPLC/MS and other scientific equipment.
  • Perform method/process development for improved oligonucleotide synthesis and purification processes.
  • Author standard operating procedures and maintain well documented records.


Required Skills and Expertise

  • A PhD in nucleic acid chemistry or organic chemistry. Candidates without a PhD with strong experience in industry will also be considered.
  • A strong record of oligonucleotide synthesis, purification, and analysis of oligonucleotides
  • Expertise in nucleoside chemistry and chemical modifications of oligonucleotides.
  • Proven ability to conduct self-directed research, troubleshooting and work effectively in a dynamic environment with a diverse team.
  • Experience in using automated synthesis platforms.

Desirable Skills and Expertise

  • Knowledge of aptamer therapeutics, aptamer generation, or aptamer discovery.
  • Experience in using LCMS instrumentation and interpreting data.
  • Background experience in development, production, and purification of novel phosphoramidites for integration into oligo synthesis workflows

Salary and Benefits

  • Salary range: £ 27,500 – £31,500
  • 25 days annual leave plus bank holidays
  • Employer contributions pension scheme
  • Gym membership (David Lloyds)
  • Private Healthcare
  • Free on-site car parking
  • Regular team events
  • Located in one of the best cities in the UK
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