Principal Scientist - Upstream Process Development

Hyper Recruitment Solutions
Closing date
18 Jan 2022

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Contract Type
Full Time
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Job Details

We are currently looking for a Principal Scientist - Upstream Process Development to join a world leading CDMO focused on the Development of life saving Protein based therapeutics. As the Principal Scientist - Upstream Process Development you will be responsible for leading and growing a team of Upstream Development Scientists, whilst also continuing to work hands-on with the mammalian upstream processes.

This is an exciting opportunity for an experienced Mammalian Upstream scientist keen to work for a Global organisation where they can further develop their career in an organisation focused on staff personal and professional development. This is a Team Leadership opportunity that does not require extensive prior leadership experience.


Your duties as the Principal Scientist - Upstream Process Development will be varied however the key duties and responsibilities are as follows:

1. You will develop, optimise and establish the mammalian upstream process capability to produce high quality cell culture harvests. It will be your responsibility as the Principal Scientist to work hands-on in order to deliver the projects and platform development activities.

2. It will be you and the USP Teams' role to transfer and support the developed processes to internal pilot plant manufacturing and transfer processes to external clients.

3. As the Principal Scientist, you will provide scientific and technical leadership while creating and maintaining risk assessments, carrying out media and feed development, as well as technology transfer and scale-up.

4. You will work closely with the Cell Line Development, Downstream Process Development, Analytical Development, Research Manufacturing and Quality teams to develop and establish new techniques and recommend alternative approaches and potential solutions to cell culture issues.


To be successful in your application to this exciting opportunity as the Principal Scientist - Upstream Process Development we are looking to identify the following on your profile and past history:

1. Relevant BSc/MSc degree in a Scientific degree (e.g. Cell Biology, Biochemistry, Biotechnology, Food Science, Biological Sciences, Biochemical Engineering, etc.) is essential. A PhD would be beneficial.

2. Proven industry experience in biologics, cell or viral upstream process development is required. Mammalian Cell Culture experience is also a prerequisite for this role.

3. A working knowledge and practical experience with mammalian upstream process development and working with bioreactors (e.e Single-use, wave bag, stirred tank, Ambr15, Ambr250) is necessary. Work with cell stock 'out of freeze', seed train development and production bioreactor optimisation will be beneficial.

Key Words: Upstream | Process Development | Principal Scientist | USP | Mammalian | Cell Culture | Bioreactor | Ambr | Biotechnology | Biologics | Team Lead

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer who are certified by Investors in People for talent development. We therefore welcome applications for any interested parties who fulfil the role requirements for this position. HRS is a company exclusively supporting the science and technology sectors, and is made up of a collaboration of recruitment professionals and scientists. We look forward to helping you with your next career moves.


Hyper Recruitment Solutions is a specialist and highly compliant recruitment consultancy dedicated to the Science and Technology sectors.

Hyper Recruitment Solutions (HRS), founded and run by Ricky Martin and in partnership with Lord Alan Sugar, has a wealth of recruitment expertise as well as compliance and commercial awareness. We offer a range of permanent, temporary and contract staff.

Our vision is to provide recruitment solutions which will assist in the improvement and quality of life for all. To do so, HRS will focus on the support of sectors whose primary focus is in making the world a better place. This could be working for a Pharmaceutical company who is developing new and existing therapeutics or an FMCG business who is making the latest consumer products in a sustainable and efficient way. We want to provide a service to those areas of actual need which will have an impact on us all.

We provide services across a broad range of industries including the following specialist sectors:

• Biotechnology
• Pharmaceutical
• Medical Device
• Clinical Research
• Food / FMCG
• Engineering
• Science

With all jobseekers we are looking to form close relationships where we can offer you the most accurate and useful advice. We intend to not only find and present the most ideal career options to you, but we want to provide advice on the entire recruitment process. We are a business who listens and advises and as shown on our website we have a clear ‘candidate commitment’ to ensure your search is in the most professional and capable hands. Some of the key areas we focus on include:

• Quality Assurance (including Qualified Persons)
• Clinical Research (all phases and therapeutic fields)
• Bioinformatics
• Research & Development
• Consumer Insight and Sensory
• Lean and Continuous Improvement
• Engineering (all disciplines)
• Manufacturing, Scale up and Technology Transfer
• Packaging and Sustainability 
• Medical Affairs
• Sales and Business Development
• Information Systems & Technology
• Executive Appointments

HRS has been awarded membership to the REC (Recruitment and Employment Confederation) and APSCo (Association of Professional Staffing Companies). This is to assure all clients and candidates that our processes and practices comply with all relevant government and recruitment industry regulations.

Lord Sugar, Ricky Martin and everyone at HRS look forward to working with you. Please do not hesitate to visit our website or contact us via
Telephone: 02032 255 120

Or any of the social media routes below: 
Linked in
Google +

Find Us
0203 910 2980
Amshold House
Goldings Hill

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