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Senior/Principal Bio-Conjugation Scientist

Entrust Resource Solutions
Alderley Edge, Cheshire
Competitive Salary
Closing date
25 Dec 2021

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Senior/Principal Bio-Conjugation Scientist

We have an exciting opportunity for a highly skilled, hands-on Senior/Principal Bio-Conjugation Scientist to join our client, an early-stage biotechnology company designing the next generation of highly specific cancer therapeutics.  This is a fantastic position that provides second to none training and support for future development, as well as offering you the chance to take a ‘step up’ and rise to a new challenge!

Using your prior experience of ADC conjugation techniques, you will be responsible for performing quality control tests to assess the quality of the conjugated molecules, as well as supporting ongoing analytical requirements.  You will also have the opportunity to shape and define the overall bioconjugation strategy of the company, including implementing new bioconjugation solutions and putting forward improvement ideas.

Tasks will include:-

  • Perform routine/novel laboratory bioconjugation experiments to support internal projects
  • Lead and advise on the design and development of new and existing ADC drug candidates
  • Drive the company’s conjugation strategy through by providing scientific ideas and technologies
  • Carry out and oversee the conjugation of small molecules (eg. cytotoxic drugs, fluorescent labels) and polymers to antibodies and proteins using a range of linker chemistries
  • Characterise antibody and protein conjugates using analytical chromatography techniques (HIC, SEC, IEX) in order to ensure reagent suitability for downstream cell-based assays. Put in place a robust QC workflow that supports reagent suitability at every stage of a project stage.
  • Define and implement a bespoke antibody and protein conjugates developability assessment regimen
  • Own and continuously improve laboratory housekeeping and implement/maintain a safe working environment in line with HSE guidelines when working with cytotoxic agents. Train and mentor more junior scientists in the handling of conjugated proteins for use in downstream assays.
  • Implement, own and regularly review SOPs, Ras and CHOSHH in compliance with Health and Safety procedures.
  • Champion data analysis of bio-conjugation experiments and bring forward proposals to address molecule or chemistry challenges.


We would like to hear from you if you have a positive can-do attitude with a good sense of humour, as well as having a PhD in Chemistry/Protein Biochemistry or related science discipline with 5 years’ experience in performing ADC bio-conjugation to proteins and antibody (formats) using a variety of linker-payload systems.

For more information, please contact Andy Cuthbert on 01606 818295 or email


Entrust Resource Solutions (ERS) is a resourcing group comprising of three like-minded consultancies operating within the life sciences, healthcare and technology industries Globally. – Entrust People Ltd – Horton International UK Ltd – SCI Search and Selection Ltd

Finding the best talent in the market is critical to the growth and ongoing improvement of every business. We help our clients navigate talent demands from bench to board with our tailored search and resourcing solutions. With our in-house knowledge of the life sciences industry, we have developed a consultative, proactive and creative recruitment solution for our clients across the UK, Europe & US. We tailor our strategy to best suit the needs of each individual client, working with them to understand their current and future growth plans. 

We specialise in the following disciplines across UK wide Life Science / scientific sectors :-

  • Research and Development - Analytical Chemistry, Toxicology, Drug Discovery, Formulation, Process Chemistry, Quality, Validation, Project Management, Synthetic / Organic Chemistry
  • Pharmaceutical Development - Clinical Development, Clinical Operations, Medical Quality, Data Management, Regulatory Affairs, Safety, Bio Statistics
  • Technical Support - Manufacturing, Engineering, Supply Chain, Quality Assurance, Quality Control, GMP Operations
  • Commercial - Manufacturing, Engineering, Supply Chain, Quality Assurance, Quality Control, GMP Ops

Our talented team of scientists and life science experts have a wealth of experience across the UK and European markets. From our three offices across the UK, we service roles from bench to board, supporting your full hiring needs, including executive search, permanent and contingent talent planning.

We manage the full hiring process, reliably and comprehensively, until a successful placement is made. We offer our clients a first-class service, from understanding your current and future hiring plans and comprehensive candidate searches, to timely and relevant CVs for interview consideration and offer negotiation, all with regular communication on our progress.

For candidates, we offer an unparalleled understanding of their industry and intended career progression, enabling us to secure the best fitting roles available in the industry.

Website : www.

Phone : 01224 907990 / 01606 818290




Find Us
01224 907990 / 01606 818290
Head Office
River Court
5 West Victoria Dock Road
DD1 13JT
United Kingdom
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