Job title: Senior Scientist – Analytical Chemist
Reporting to: Principal Scientist
Location: Science Creates, St Philips Central, Bristol, UK
Hours of work: Full time, permanent
Closing date: 29/11/2021
Benefits package: £30,000 - £37,000, dependent on experience
Expected start date: Flexible, from February 2022
This is an exciting opportunity to join a growing and vibrant research team that combines expertise in bioinformatics and computational design, peptide and protein chemistry, biotechnology, and machine learning. In this post, you will develop techniques and protocols for the identification of specific small-molecule analytes that are present in biological samples that directly bind to and interact with the component proteins of our sensor, and correlate this to sensor output and prediction. In addition, we are a small and nimble company with flexibility being highly valuable to us. As such, from time-to-time, you may be required to briefly switch to working on other projects to meet broader deadlines.
We are currently advertising to fill two Senior Scientist (Chemist) posts: Both the position advertised here; and for a Surface Chemist. We encourage any candidates to read the description for both posts and apply as appropriate. Depending on how the recruitments process unfolds, you may be considered for either position depending on skillset and once the make-up of our entire team becomes more evident.
We are seeking exceptional candidates with a PhD in Chemistry, Analytical Chemistry, Physical Chemistry or a related discipline. Expertise in one or more of fluorescence spectroscopy, biophysics, mass spectrometry, NMR, proteomics, metabolomics, and peptide/protein handling would be a distinct advantage, and applicants with multiple of these skillsets are encouraged to apply. We are keen to receive applications from ambitious, and energetic individuals with an interest in translating laboratory-based research into real-world applications.
Roles and responsibilities
- Assisting with all aspects of research conducted in the laboratory as and when required.
- Keeping accurate records of experimental procedures, workflow, and data.
- Analysing and interpreting data and presenting work in a clear and concise fashion at regular company meetings and to external collaborators.
- Develop robust methods for identifying and characterising small-molecule interactions with barrel-forming peptides that are the basis of our sensor.
- Correlate small molecule-barrel interactions with sensor output data and identify candidate molecules allowing us to discriminate between healthy and diseased patient cohorts.
Person specifications Relevant skills & experience
- An ambitious team player who can conduct themselves in a polite, respectable, and professional manner when dealing with others
- Extensive practical laboratory experience
- Ability to formulate and execute an experimental work plan
- A demonstrable ability to innovate and think laterally
- An ability to work independently and as part of a team
- An ability to forge new collaborative partnerships and to work alongside third parties.
- Ability to take accurate records of work carried out
- Ability to liaise and communicate effectively with a wide variety of internal and external contacts.
- Excellent numeracy and literacy, and computer literacy
- NMR of biological samples
- Expertise in the handling and analysis of fluorescent molecules.
- Biophysical analysis of peptides/proteins.
- Experience with the handling and analysis of biological fluids
- Experience with high-throughput assays and functional assays of peptides/proteins
- Experience working with peptide/protein array technologies
- Experience working with robotics and automation pipelines.
- A keen interest in learning computer programming and scripting
- Experience in using electronic notebooks
- Experience of working in a multidisciplinary team in an early-stage company
- Experience of GLP, GMP and/or GCLP
- A PhD in chemistry or a related field.
Eligibility and expectations
In order to qualify for this position, you must be authorised to live and work in the UK. If you are applying from outside of the UK, you must state in your cover letter your right to work status e.g., UK citizen, EU Settlement Scheme, other
Rosa has a COVID-19 risk assessment that is continuously updated to follow the latest Government and PHE advice and follow the safety restrictions of Science Creates and The University of Bristol. Most of the work is expected to take place in Rosa’s dedicated laboratory space at Science Creates, St Philips Central, Albert Road, Bristol, BS2 0XJ and occasionally within Professor Dek Woolfson’s laboratory located in the School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS.
In line with current guidelines surrounding social distancing and working from home, the overall work pattern will be fluid and we encourage blended working for the foreseeable future. The role may also involve short visits to other organisations in the UK and abroad, with the potential for occasional overnight stays.
At Rosa Biotech, we value diversity. We are an equal opportunities employer and welcome employees who meet the job requirements, regardless of gender, ethnic origin, disability, age, religion or sexual orientation. You must have respect for others and a commitment and enthusiasm for high standards and continuous improvement.
Important information regarding your application
By making this application, you confirm your consent for Rosa Biotech to hold details of your application and associated personal information strictly for recruitment purposes. Rosa Biotech will keep all recruitment documentation for 12 months following the job position being filled. The successful candidates' recruitment documentation will be kept in accordance with Rosa Biotech's Internal Personal Data Policy.
If you wish for your information to be removed from our records before that date, please contact firstname.lastname@example.org stating "Personal information removal request" in the title of your email or by writing to us at Rosa Biotech Limited, Albert Road, Bristol, BS2 0XJ.
How to apply
Please send your CV with a cover letter to: email@example.com, including "Job application – Senior Scientist - Analytical Chemist " in the subject line to apply for this role.
The deadline for application is 5 pm UK time, Monday 29th November 2021.