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Internship for Senior Analytical Chemist or Junior Analytical Chemist

Employer
Biopharma Stability Testing Laboratory Ltd
Salary
£16,000 to £21,000
Closing date
11 Aug 2019

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Salary: £16-21k (experience dependant)

Start Date: 1st September 2019 (or could be brought forward)

Duration: 6 months Internship (could lead to permanent full-time position)

Location: Nottingham BioCity

Closing Date: Sunday August 11th – Interview to be held August 19th / 20th

The position will involve working in the area of pharmaceutical analysis with a focus on analysis of parenteral drugs in a GMP / GLP laboratory. If you are interested in research within a regulated environment this could be a great opportunity to grow your career.

Working as part of the Analytical and QC team you will perform a key laboratory-based role in the chemical analysis of licensed parenteral drugs according to standard stability testing requirements including: ICH/USP/EP and NHS yellow cover document requirements, within a GMP / GLP laboratory.

In this role you will work closely with and report to the Quality Assurance director ensuring ongoing product quality and adherence to ICH/FDA/MHRA guidelines and internal Quality Management Systems. You will be expected to liaise with other scientific staff in response to any OOS results, investigating and closing out non-conformances.

The role will involve a variety of tasks including:

  • Development of a surface wipe process for recovery of pharmaceutical drugs from a variety of surface types.
  • Assessment and optimisation of recovery rates for pharmaceutical drugs from different surface materials/types.
  • Development of analytical methods for UHPLC-DAD/HPLC-DAD-MS
  • Analysis of samples using HPLC/UHPL-DAD and UHPLC-MS, FTIR, UV/VIS.
  • Investigation of non-conforming samples, CAPAs, data evaluation and reporting.
  • Method Development & Method Validation supporting analysis and quantification of low-level trace surface contamination by a range of  pharmaceutical drugs.
  • Write cGMP Quality documents including Standard Operating Procedures, laboratory equipment procedures and investigational protocols.
  • Be responsible for the operation, maintenance, training delivery as an expert and maintain operating procedures for at least one piece of laboratory equipment i.e UHPLC-DAD-MS.
  • Author and approve (where appropriate) STPs and SOPs within the analytical laboratory.
  • Perform technology transfer (method transfers) and critically evaluate data.
  • To prepare and review analytical protocols/reports and to perform raw data analysis and verification through the Chromeleon data system software (CM 6.8 and CM 7.2).

To be considered you must have the following skills and experience;

Essential:

  • Experience of developing methods for UHPL/HPLC with DAD and MS detection.
  • Previous experience of operating UHPLC/HPLC systems.
  • A BSc in a relevant chemical science, or MSc, MChem, MSci or HND/HNC also in a relevant chemical science (HND/HNC is acceptable if in combination with at least two years industrial experience as an analyst using HPLC-DAD/MS systems).
  • The ability to take ownership of, plan and execute the provided project deliverables to time and on budget.
  • Willingness to travel to different customer sites where required (within the UK).
  • Willingness to work with hazardous drug materials including antineoplastic and cytotoxic compounds used in treatment of cancer (using appropriate PPE and safety cabinets to mitigate occupational exposure).

Desirable:

  • Experience of operating: FTIR, GC, UHPLC-DAD, UHPLC-MS, UHPLC-MS-MS, SEM etc equipment and knowledge of computerised data systems software and data management.
  • Proven track record of method development with LC-MS systems and troubleshooting is highly desirable.
  • Good analytical skills with the ability to prepare calibration samples, QCs and various parenteral pharmaceutical samples from a variety of container systems (although training will be provided) for quantification and identification of any substance related impurities.
  • A Post Graduate qualification and / or Doctorate in a relevant subject area.

Please apply by sending your CV and a covering letter stating why you believe you are suitable for the Internship (how your experience and skills evidence the Essential criteria) and what you hope to gain from it to Rebecca Weston (rebecca@biopharmatesting.co.uk).

All applicants for this job should be able to prove they are legally entitled to work in the UK

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