Duration: 12-month fixed term (in the first instance)
About the role:
We are seeking an experienced, talented and dedicated synthetic and/or medicinal chemist to join our team at the Drug Discovery Unit led by Prof. Caroline Springer at the Cancer Research UK Manchester Institute. The position will be laboratory-based and will require independent design and implementation of complex synthetic routes to yield challenging new chemical entities.
You will bring excellent theoretical and practical expertise in synthetic and/or medicinal chemistry alongside enthusiasm, creativity and problem solving. A track record in the synthesis of biologically relevant molecules and the experience to make key intellectual contributions to projects are also desirable. You will have a degree in Chemistry or related subject (or equivalent relevant experience) along with demonstrable, current expertise in synthetic organic chemistry. PhD or postgraduate level qualification in synthetic organic or medicinal chemistry or related subject (or equivalent relevant experience), would be an advantage but is not essential. Experience in PROTAC chemistry would also be an advantage but is not essential.
The Drug Discovery Unit integrates medicinal, computational and synthetic chemistry with in vitro cellular biology and in vivo capability. The unit has established facilities to enable state-of-the-art biological and clinical target assessment and validation, small molecule drug design and synthesis and the biological evaluation of the resultant compounds. The centre builds upon fundamental biology discoveries made within the CRUK Manchester Institute to investigate novel drug discovery targets in an attempt to provide new chemical entities for the treatment of unmet clinical needs in cancer patients.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at The Oglesby Cancer Research Building in South Manchester and at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK MI Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
The Drug Discovery Unit employs state-of-the-art facilities directed toward the discovery of novel, clinically relevant treatments for a variety of different cancer types. Details of the Unit itself can be found at (http://www.cruk.manchester.ac.uk/Research/CRUK-MI-Groups/Drug-Discovery/Home).
How to apply?
To apply for this position please visit our job section of our website: https://www.cruk.manchester.ac.uk/recruitment/candidate/searchvacancies (currently running alongside our main CRUK MI website page: http://www.cruk.manchester.ac.uk/)
The deadline for receipt of applications is: 22 July 2019.