Closing Date 02 December 2018
The Drug Discovery Unit (DDU) (www.drugdiscovery.dundee.ac.uk/) at the University of Dundee is seeking a driven, proactive and experienced organic chemist, with hands on expertise and a track-record of delivery in flow chemistry.
The DDU, is a “Biotech style organisation” of 100 dedicated multidisciplinary scientists that covers all aspects of drug discovery up to candidate selection. The Unit’s mission is to discover and expedite the development of new drugs for major diseases, e.g. malaria, TB, cancer, neurodegeneration, delivering a growing portfolio of development candidates. The Unit is housed in a state-of-the-art building, with cutting-edge equipment and automation for drug discovery.
The post is within the DDU’s expanding Synthetic Methodologies Team. The team has a remit to facilitate the synthesis of compounds for biological screening through the delivery of building blocks, development of new chemical routes and methods, and the championing of high throughput chemistry.
The successful applicant will develop new chemistry to scale up final products and intermediates using our existing flow chemistry equipment to support our drug discovery programmes. Working closely with synthetic organic, medicinal and analytical chemists across a range of projects, you will help to develop our capabilities in this area, including identifying strategies, new methodology and equipment, and help advance an internal culture of scientific excellence by identify emerging trends in the field. You must be committed to establishing yourself as a flow chemistry expert within the DDU and must be enthusiastic about mentoring those new to the field.
This open-ended post is available from now.
The starting salary will be within Grade 7 (£32,236 - £39,609) depending on the experience of the candidate. A relocation allowance is available.
• Design and optimisation of robust, sustainable processes to scale up intermediates and final compounds, and synthesise compound libraries
• Timely delivery of pure, characterised compounds and/or compound collections
• Development and implementation of flow chemistry and continuous processing technologies within the DDU
• Optimisation of flow methodology for purity and delivery time
• Discovery and validation of synthetic methods that are amenable to flow chemistry
• Integration of these activities with the DDU’s automated purification capabilities
• Identification and selection of equipment to support flow chemistry
• Maintenance of flow chemistry systems
• Dissemination of the use of flow chemistry to the wider DDU medicinal chemistry group
Skills and Knowledge:
• Ph.D. in chemistry or equivalent experience in organic synthesis
• Demonstrated track-record of expertise and delivery in the field of flow chemistry, ideally in the scale up of compounds and multistep synthesis of compound libraries.
• Demonstrated expertise in organic chemistry principles
• A willingness to work flexibly to meet milestones
• Good time management and organisational skills
• Strong interpersonal, communication and presentation skills
• Familiarity with high-throughput purification equipment
• General IT skills
• Familiarity with programming and lab automation
• Experience working at >5g in batch
• Maintenance of a strong external network in the academic community
A few facts about The School of Life Sciences at Dundee:
• The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine
• The University of Dundee achieved the highest aggregate rating in Biology among all UK Universities in the 2014 Research Excellence Framework (REF) assessment.
Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills.
Please note applicants who applied for the flow chemistry position reference SLSC0468 should not reapply for this position.
The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.