Graduate Scientist - RSC Funded Internship
Job Title: RSC Funded Internship-Graduate Scientist
Antikor Biopharma based at the Stevenage Bioscience Catalyst has an excellent opportunity for a talented Chemistry graduate to join them for a 3 months internship, as a Graduate Scientist. The intern’s laboratory-based project would focus on the synthetic chemistry for new drug/linker combinations, taking these through small scale protein bioconjugation experiments and producing antibody drug conjugates for further characterisation and study. Although based in chemistry, the successful candidate will be exposed to all facets of Antikor’s scientific R&D activities.
Salary: £1333 per month for 3 months internship, after which the position will be reviewed.
Holidays: 20 days per annum pro rata
Working hours: Full-time, 9 am-5.30 pm
Degree / relevant disciplines: BSc (minimum), MChem (desirable), PhD (preferred) in chemistry, persons returning to work after a career break
Please note: only GRADUATES can be considered for this position
About the company:
Antikor Biopharma is developing a unique and innovative class of Antibody Drug Conjugate (ADC) therapy called Fragment Drug Conjugates (FDCs). FDCs offer potential benefits over larger ADCs in the treatment of solid tumours due to their rapid penetration, delivery of high amounts of cytotoxic payload and faster clearance from normal tissue, resulting in better tolerability and a high therapeutic index. Antikor is now developing its first oncology products in areas of high clinical unmet need like gastric cancer. Recent deals in the FDC area demonstrates for the first time how valuable this emerging area is and Antikor’s more advanced and focussed approach creates a major opportunity to bring differentiated products for solid cancers in to clinical development.
Antikor has recently completed an Innovate UK project on a class of natural product DNA damaging agents as payloads for antibody drug conjugates. The project highlighted a number of key design features that need to be considered to enable high drug loadings to be achieved on Antikor’s proprietary antibody format. The intern’s project would be a focussed effort to complete the synthetic chemistry for one of these new drug/linker combinations and take these through small-scale bioconjugation studies. The data generated by the intern’s project will help us refine linker design focusing on the impact of both hydrophilicity and the length of linker on antibody binding. The project will involve synthetic medicinal chemistry, linker design and synthesis, bioconjugation and protein chemistry.
Skills and Experience they will gain:
Antibody drug conjugates sit at a unique interface between biochemistry/chemistry. A key learning outcome will be understanding the role medicinal chemistry is playing in the development of biotherapeutics at this interface and the practical application of organic synthesis in cross-discipline areas like protein bioconjugation.
- Practical experience in natural product chemistry, new synthetic methods and multistep synthesis
- Drug-linker design and understanding proteins and protein bioconjugation
- Advanced experimental and analytical techniques such as HPLC (for conjugate analysis), LC-MS (for conjugate characterisation), Biotage (for purification)
- Learn and understand the commercial importance of generating high quality data, critical for IP, publications and raising investment
- Importance of team working, cross-disciplinary communication, flexibility and working to testing timelines
Please email your CV and cover letter outlining your interest in this role to firstname.lastname@example.org Please ensure that you have the right to work in the UK before applying and that you are willing and able to live within a commutable distance of the company .