Synthetic Organic Chemist – Drug Development

London (East), London (Greater) (GB)
01 Aug 2017
31 Aug 2017
Contract Type
Full Time


Synthetic Organic Chemist – Drug Development


Location: London


Salary: Competitive


If you’re inspired to work for a world premier biotechnology company delivering life-changing products– join us.




MedImmune is the global biologics research and development arm of AstraZeneca. We work as partners in bringing life changing medicines to patients, sharing and benefiting from each other's strengths. Spirogen sits within the Medimmune group and is highly innovative, having developed a potent and flexible class of ADC (Antibody Drug Conjugate) payloads based on their proprietary PBD (pyrrolobenzodiazepine) platform technology, with marked improvements in terms of activity, ease of manufacture and therapeutic index.


Our science lives beyond our labs – our global perspective means we use talent and expertise from all over the world to make our medicines a success. With an exciting research pipeline, this is a great time to develop your career with Spirogen.


The Role and Responsibilities




This is an exciting opportunity to work within the Chemistry Group at Spirogen. As part of the group you will work on the design, synthesis and characterisation of novel drug payload molecules and warheads, for antibody conjugation and biological evaluation. In addition, you will work in a multidisciplinary matrix environment and support research at the chemistry-biology interface to address a range of key challenges associated with therapeutic biologics. As part of your role you will be expected to write reports, patents, MTAs and work plans. You will also source the equipment, chemicals and specific reagents required to do your work as well as assessing lab protocols and setting up standard operating procedures. You will be a hands-on member of the group who enjoys working at the bench on synthesis projects and synthesizing complex organic molecules.


Essential Requirements


·       PhD in Chemistry, Medicinal Chemistry, or other relevant scientific discipline.


·       Good hands on experience of synthetic research chemistry.


·       Experience of multi-step synthesis, analysis and purification of complex organic molecules (multi-gram to milligram scale).


·       Experience of modern synthetic chemistry techniques.


·       Experience of modern analytical chemistry techniques (NMR, LC-MS, HPLC etc.).


·       Good communication and document writing skills as well as IT skills.




Desirable Requirements


·       Proven track record of success in the synthesis of complex compounds.


·       Pharmaceutical industry experience.


·       Experience of working with CRO/CMOs for chemical synthesis.


·       Understanding of basic biology, especially DNA Processes.


·       Basic understanding of intellectual property management.




Next Steps – Apply today!


To be considered for this exciting opportunity, please complete the full application on our website.  If you know someone who would be a great fit, please share this posting with them.


The link to the website and advert is:


The closing date for this application is 30th August 2017


MedImmune is an equal opportunity employer. MedImmune will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. MedImmune only employs individuals with the right to work in the country/ies where the role is advertised.


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