Principal Translational Scientist - Biomarkers

19 Jun 2017
17 Jul 2017
Georgia Walden
Contract Type
Full Time
An exciting opportunity for a Principal Translational Scientist - Biomarkers has become available to join a leading biotechnology company based in the Cambridgeshire area. As the Principal Translational Scientist - Biomarkers you will be responsible for development and implementation of the translational strategy for novel pipelines of early phase bispecific mAb2 molecules for immune-oncology.


Your duty as the Principal Translational Scientist - Biomarkers will be to guiding internal and external teams to produce quantitative translational datasets to enable the selection of best-in-class molecules. Your other key duties and responsibilities are as follows:

1. Provide technical and scientific contribution to the biomarker strategy while working as part of a multidisciplinary team to develop the translational and clinical biomarker strategy.

2. Liaise closely with preclinical pharmacology and discovery groups to characterize the fundamental biology of targets and translation across species to ensure appropriate endpoints are measured for target engagement and pharmacodynamic effects.

3. Develop hypothesis driven approaches to the targeted use of quantitative biomarkers and oversee the technical and operational aspects of mechanistic biochemical biomarker analysis .

4. Continually assess the latest technologies available and provide input to the internal and external capabilities required to support the portfolio needs.


To be successful in your application to this exciting opportunity as the Principal Translational Scientist - Biomarkers we are looking to identify the following on your profile and past history:

1. Relevant PhD in a Life Sciences discipline or equivalent experience.

2. Proven industry experience as a biomarker scientist with demonstrated ability supporting translational and clinical mechanistic biochemical biomarker activities to assess target exposure, engagement/ occupancy and pharmacodynamic effects in collaboration with internal and external partners e.g CROs, consultants, and collaborating organisations.

3. Practical experience utilizing data e.g via statistical analysis and data visualisation, from a broad arrange of technology platforms to assess biomarkers including but not limited to immunoassays, flow cytometry, omics platforms etc.

Key Words: Antibodies | Biomarkers | Translational Pharmacology | Translational Strategy | Pipeline development | PK/PD | Drug Discovery | Bioinformatics |

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer who are certified by Investors in People for our talent development. We welcome applications for any applicant who fulfil the role requirements for this position. HRS is a company exclusively supporting the science and technology sectors, and is made up of a collaboration of recruitment processionals and scientists. We look forward to helping you with your next career moves.

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