Graduate Associate Scientist - Internship
Cyclofluidic Ltd, based in Herts, is currently offering 3 months internship, for a talented Chemistry graduate. This is a lab based role within the chemistry team. However, the degree of integration is such that the successful candidate will be exposed to all facets of the company's scientific activities.
The Cyclofluidic closed-loop platform, CyclOps, is a pioneering technology for the rapid advancement of drug discovery programmes. Driven by an artificial intelligence algorithm, it redefines the classic design-make-test paradigm by uniting chemistry and biology in a highly integrated and automated fashion. The result is reduced cycle times and increased productivity. Inventiveness is enhanced through the exploration of greater, and sometimes unexpected, areas of chemical space.
Salary: £4000 - 3 months internship
Working Hours: 9.00am-17.30pm, with 1 hour lunch
Holidays: 26 days per annum pro rata
Start date: Mid July to end of August 2017
Degree / relevant disciplines: Chemistry, BSc, MChem, PhD
Please note: only GRADUATES can be considered for this opportunity
Closing Date: 23rd June 2017
About the company
At Cyclofluidic we aim to translate our decades of pharma experience and our passion for drug discovery into pre-clinical molecules with the highest chance of becoming innovative medicines. We are innovative in both our science and our business; fast and flexible in the way we work to solve medicinal chemistry challenges. We work in true partnership with our collaborators, leveraging the CylOps™ platform to solve medicinal chemistry problems at speed, delivering the highest quality data and results in the shortest possible times with the highest standards of confidentiality.
The primary responsibility will be the synthesis the synthesis and purification of new molecules; the successful candidate will be closely involved with the bio assays and the gathering of SAR data. Synthesis will be carried out on the both on the automated platform, using flow and other techniques, and in batch mode, using the breadth of modern synthetic organic chemistry techniques and methods. Purification of final compounds will use the state-of-the-art system built into CyclOps. The intern will also learn standard column and cartridge techniques common for the larger-scale synthesis of intermediates.
The intern will be part of a multi-disciplinary team, comprising synthetic, medicinal and analytical chemists and biologists, working closely with colleagues to produce compounds and data for customer projects.
The intern will work on projects for customers. Cyclofluidic is too small for projects designed specifically for the intern. However, the result will a "real-life" and fully immersive experience. The length of projects tend to be such that the intern is likely to be able to see one from start to finish.
The intern will be fully-supported by their manager in every aspect of their work and gain valuable experience of new chemistry and new technology.
Expected learning outcomes
The intern will gain a range of technical and scientific skills, which will include:
- New synthetic methods, expanding what they will have learnt at university.
- Flow synthesis.
- Automated chemistry and purification through the use of the CyclOps platform.
- Small scale (microgramme) synthesis and purification.
- An in-depth understanding of HPLC
- Library synthesis.
- Medicinal chemistry compound design.
- Electronic lab notebook, and IT skills required to submit compounds and analyse the output of CyclOps.
The intern will also gain transferable skills, which will include:
- Team working.
- Planning and personal organisation, which will be vital for successful use of the CyclOps platform.
- Communication, both with colleagues and customers, in oral and written forms.
- Working to testing timelines.
- Keeping up to date with administrative tasks.
- IT skills.
- Problem solving.
- Experience required - Essential
Synthetic organic chemistry, including route design
Analytical chemistry - HPLC
- Experience required -Desirable
- IT skills required -Essential
Working with Excel, e Molecules and Reaxys
- IT skills required -Desirable
Familiarity with Pipeline Pilot and Experience of working with an ELN
- Transferable skills required e.g. behaviour in a team, attention to detail, organisational skills – Essential
Attention to detail
Highly organised in and out of the lab
Open, timely and anticipatory communicator
An active listener
- Transferable skills required e.g. behavior in a team, attention to detail, organisational skills -Desirable
Able to work harmoniously in a close-knit team
GRADUATES holding Chemistry related degree. This internship is only open to:
- Person returning to work after a career break
The intern will be able to contribute at the limits of their capability. Someone returning to work may have particularly valuable and pertinent skills.
The intensity of the project work and the small size of the company make part-time working difficult to accommodate
Please ensure that you are willing and able to live within commutable distance of the company site before applying. This placement is located in Herts. Cogent Life Science Placements Service are managing the recruitment for this internship at our client's request, therefore we ask that applications are made through our website please.
The Royal Society of Chemistry is the world’s leading chemistry community, advancing excellence in the chemical sciences. 54, 000 members and a worldwide knowledge business that spans the globe, it is the UK’s professional body for chemical scientists; a not-for-profit organisation with 175 years of history and an international vision for the future. The Royal Society of Chemistry as part of its small companies programme, EnterprisePlus (www.rsc.org/sme) has granted a small number of companies funding for internships for those already graduated including those returning to work. You will need to be a member of the Royal Society of Chemistry by the time you take up the internship and can join here http://www.rsc.org/membership-and-community/join/
If you have an gross income (before tax) income below £26,000 you can access a 50% discount below per annum http://www.rsc.org/globalassets/03-membership-community/join-us/reduced-subscription-claim-form.pdf?id=6324
Membership also include significant career support including face to face or telephone career consultations http://www.rsc.org/careers/