Crystec Ltd - Associate Research Scientist - Undergraduate Placement
Excellent opportunity to gain hands-on work experience for a talented Chemistry undergraduate!
A key component of the placement will be completion of an assigned independent project focused on processing pharmaceutical and biopharmaceutical molecules using supercritical fluid (SCF) technology. It is estimated that the student will spend approximately 50% of their time at Crystec on their independent project, with the remaining time supporting the science team and wider team e.g. business development. The programme may also involve some liaison with other academic institutions, for example Professor Helen Philippou and her team at the University of Leeds In addition to the independent project the student will be expected to integrate with the science team, contributing to smooth operational running day-today.
Primarily this will involve supporting in-house and external client projects in every respect. In doing this, the student will be running supercritical fluid (SCF) rigs on a daily basis and carrying out COSHH assessments as required. A major aspect of the work will be in conducting analysis as needed (PXRD, SEM, DSC, TGA, NMR). This stretches beyond the generation of data and will include detailed interpretation of results, subsequently contributing to scientific project meetings and writing reports as required.
The student will receive high quality training from experienced members of Crystec staff in the use o SCF rigs and appropriate analytical equipment, with support from staff at Crystec and the University of Bradford Analytical Centre as needed. Although full raining will be provided and support available (from the placement supervisor as well as other member of the science team), the student will be expected to work autonomously and confidently, independently managing their time to ensure deadlines are met.
This will include prioritisation of experimental, analytical and desk-based work as well as timely reporting to their supervisor as agreed.
One of the key objectives of the placement will be to facilitate an introduction in to industry, with a focus on professional working practices. The project will involve processing biotherapeutic or small molecule agents using SCF technology in order to advance the design of a superior pharmaceutical product. The pharmaceutical industry is in need of innovative technology solutions in order to overcome the increasing challenges associated with modern pharmaceutical products, for example poor solubility, stability or low dose. Given SCF is a high yielding, single step process, it provides an attractive alternative to more conventional processes, e.g. lyophilisation and micronisation, which can damage sensitive molecules and offer less control over the final product generated.
The placement ultimately aims to provide exposure to SCF processing, allowing the successful applicant to experience first-hand use of a highly innovative and niche crystallisation technique. This will include expanding understanding of phase behaviour, polymorphism and crystallisation, as well as an increased awareness of the impact that particle morphology, size, size distribution etc. can have on formulation development. Much of this learning can then be applied in the pharmaceutical and chemical industries more broadly. It is hoped that the student will become proficient in the use of analytical equipment previously mentioned (e.g. PXRD, DSC, TGA and SEM, NMR, HPLC, FT-IR and UV). The student will leave the placement, not only as a confident operator of many these pieces of analytical equipment, but will also have extensive experience in critically examining and interpreting the data generated. This experience will give the student a tremendous grounding in their future career, placing them ahead of their peers and giving them a wealth of experience in standard analytical techniques, Crystec is a small, innovative, high technology company. As such, the student will also gain invaluable exposure to all parts of the business Inevitably in a smaller organisation the day – today running of the company involves team support, and through the placement the student will unsurprisingly also gain first-hand experience of many different functions within the organisation For example, this may include supporting activities as appropriate with the Business Development Director, including attending project teleconferences with clients, supporting grant writing as needed and conducting research on potential project molecules.
We have a highly multi-disciplinary team so tutorial sessions will also be scheduled with the CSO, COO CEO and others as appropriate.
During the proposed project, the student will learn key skills to take forward in their career as a scientist They will learn how to be critical of their own and others work, and to recognise and produce excellent science. From their experience working with the business development team the student will gain an appreciation of the different roles members of staff play at Crystec and within pharmaceutical companies in general. This will allow the student to make informed decisions about their career path and their place within the pharmaceutical industry in general.
Importantly the student will be treated as a team member and so will be expected to maintain laboratory records, and health and safety practices etc. as needed. Exposure to other divisions within the company will also help to enhance the outcome from this multi-disciplinary placement.
- The student will be expected to become competent in the following: Independent use of SCF rigs
- Ability to generate and complete appropriate experimental plans
- Confident operation of XRD, SEM, TGA and DSC
- Use of NMR, HPLC, dissolution baths and UV as appropriate
- Conducting literature reviews to support project work
- Enhanced understanding of the pharmaceutical industry including formulation development, regulatory concerns and health and safety
- Writing of high quality scientific reports
- Liaising with professional scientists in academic and industrial setting
- Creating and presenting research outcomes in a professional setting
During the proposed project, the student will learn key skills to take forward in their career as a scientist They will learn how to be critical of their own and others work, and to recognise and produce excellent science. From their experience working with the business development team the student will gain an appreciation of the different roles members of staff play at Crystec and within pharmaceutical companies in general. This will allow the student to make informed decisions about their career path and their place within the pharmaceutical industry in general. Importantly the student will be treated as a tea member and so will be expected to maintain laboratory records, and health and safety practices etc. as needed. Exposure to other divisions within the company will also help to enhance the outcomes from this multi-disciplinary placement.
UNDERGRADUATES only: Working towards accredited Chemistry Degree - Projected 2:1 or higher
For further information regarding accredited courses, please visit: http://www.rsc.org/Education/courses-and-careers/accredited-courses
Please ensure that you are willing and able to live within commutable distance of the company site before applying. This placement is located in West Yorkshire. Cogent Life Science Placements Service are managing the recruitment for this placement at our client's request, therefore we ask that applications are made through our website please.
The Royal Society of Chemistry is the world's leading chemistry community, advancing excellence in the chemical sciences. With 51,000 members and a worldwide knowledge business that spans the globe, it is the UK's professional body for chemical scientists; a not-for-profit organisation with 170 years of history and an international vision for the future. The Royal Society of Chemistry as part of its small companies programme, EnterprisePlus (www.rsc.org/sme) has granted a small number of companies funding to host a “year in industry” placement. Funding has been awarded in recognition of their ability to develop and mentor an undergraduate chemist and robustness of the project content and structure in terms of its scientific content and what you will learn. This year, Crystec Ltd is a well-deserved recipient of this prestigious funding. It is expected that if you are successful in being selected for this role that you are a member of the Royal Society of Chemistry by the time you start the placement. Royal Society of Chemistry membership is just £19 and you can join online at: http://www.rsc.org/Membership/join/admission/undergrad/index.asp
Please note: only UNDERGRADUATES can be considered for this placement
Closing date: 24/03/17