Senior / Principal Scientist - Protein Sciences

Dependent on experience
01 Feb 2017
01 Mar 2017
Eve Hegarty
Contract Type
Full Time
We are currently looking for a Senior / Principal Scientist to join a growing biotechnology company based in the Cambridge area.

Your role as the Senior / Principal Scientist will be based with the Protein Sciences team, and you will play a key role in the continuous advancement of our client's immune-oncology platform and contribute to drug discovery and development. Working within the Protein Sciences group, you will take the lead role for our client in the development and delivery of analytical capabilities to support the technology platform and pipeline. Analytical capabilities are required to deliver protein engineering, research grade production and process development activities with a key focus on protein characterisation, formulation and developability assessments.


Your duties as the Senior / Principal Scientist in Protein Sciences will be varied however the key duties and responsibilities are as follows:

1. Development and delivery of analytical methods for characterisation of our client's pipeline with a key focus on protein aggregation, formulation, primary structure determination, post-translational modification characterisation and protein structure prediction.

2. Formulation, developability assessment and characterisation of antibodies

3. Analytical leadership for development programmes from early development through to GMP manufacture. You will provide leadership of a small team within Protein Sciences .

4. Representation of Protein Sciences on development programmes

5. Critical interpretation of data to draw results driven conclusions and define project progression


To be successful in your application to this exciting opportunity as the Senior / Principal Scientist in Protein Sciences we are looking to identify the following on your profile and past history:

1. PhD or equivalent relevant experience, ideally gained in an industrial environment although consideration will be given to industrially relevant academic experience.

2. You will be expected to demonstrate extensive experience and breadth of knowledge in analytical and biophysical characterisation of recombinant biotherapeutics for CMC development. (e.g. formulation, protein aggregation, protein stability and post-translational modifications including glycosylation). This includes experience in establishing and applying the following techniques: UHPLC (SEC, RP, IEX), Mass Spectrometry (including MS/MS peptide mapping of protein therapeutics), dynamic and static light scattering, capillary electrophoresis.

3. This is a senior role within the team, so you will be expected to demonstrate management and leadership of scientific teams, scientific credibility and ability to drive and influence projects through scientific expertise; proven ability to interpret complex data and excellent verbal and written communication skills

Key Words: protein sciences | Senior Scientist | Principal Scientist | biotherapeutics | glycosylation | UHPLC | SEC | RP | IEX | MS/MS | peptide mapping | DLS | DSC | capillary electrophoresis | stability

Hyper Recruitment Solutions Ltd (HRS) is an Equal Opportunities employer that is happy to welcome applications for any applicant who fulfil the role requirements for this position. HRS is a company exclusively supporting the science and technology sectors and is made up of a collaboration of scientists supporting science. We look forward to helping you with your next career moves.